New Diagnostic Criteria for Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Park, Soo Hyun; Kim, Nam Hee

J Mult Scler > Volume 8(2); 2017 > Article

Review Article

Journal of Multiple Sclerosis 2017;8(2):24-30.
Published online September 1, 2017.

다발성경화증과 시신경척수염범주질환의 새로운 진단기준

박수현, 김남희

동국대학교 일산병원 신경과

New Diagnostic Criteria for Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Soo Hyun Park, Nam Hee Kim

Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Korea

Abstract

"Precise differential diagnosis of neuromyelitis optica (NMO) and multiple sclerosis (MS) is critical because treatment and prognosis are distinct and disease modifying treatment of MS can aggravateNMO. The discovery of disease-specific aquaporin-4 antibody has facilitated differentiation of NMOfrom MS and recognition of a broader phenotypic spectrum referred to as neuromyelitis optica spectrumdisorder (NMOSD). However, distinguishing NMOSD from MS remains challenging, as there isstill an interface between seronegative NMOSD and MS. Diagnostic criteria have evolved to improvedifferentiation and early detection of MS and NMOSD. This review will focus on new guidelines forthe diagnosis of patients who are suspected of having MS or NMOSD. Journal of Multiple Sclerosis 8(2):24-30, 2017"

Key Words: Neuromyelitis optica, Neuromyelitis optica spectrum disorder, Multiple sclerosis, Magnetic resonance imaging, Diagnostic criteria