Progressive Cerebellar Atropy in a Patient with Neuromyelitis Optica Spectrum Disorder

Shin, Jong-Hwa; Seok, Jin Myoung; Cho, Eun Bin; Lee, Hye Lim; Cho, Hye-Jin; Min, Ju-Hong; Kim, Byoung Joon

J Mult Scler > Volume 7(1); 2016 > Article

Case Report

Journal of Multiple Sclerosis 2016;7(1):18-20.
Published online March 1, 2016.

진행성소뇌위축 소견을 보인 시신경척수염범주질환 1예

신종화, 석진명, 조은빈, 이혜림, 조혜진, 민주홍, 김병준

성균관대학교 의과대학 신경과학교실, 삼성의료원 신경과

Progressive Cerebellar Atropy in a Patient with Neuromyelitis Optica Spectrum Disorder

Jong-Hwa Shin, Jin Myoung Seok, Eun Bin Cho, Hye Lim Lee, Hye-Jin Cho, Ju-Hong Min, Byoung Joon Kim

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Abstract

"Neuromyelitis optica (NMO) is an inflammatory, demyelinating disease of the central nervous system characterized by attacks of optic neuritis and myelitis and the presence of antiaquaporin-4 antibody(anti-AQP4).There is paucity of data on patterns of brain or cerebellar atrophy in NMO, althoughprevious studies revealed significant brain atrophy in multiple sclerosis. We report a patientwith anti-AQP4 positive NMO spectrum disorder, who presented with generalized limb ataxia andgait disturbance and showed progressive cerebellar atrophy in serial follow-up brain magnetic resonanceimagings. Journal of Multiple Sclerosis 7(1):18-20, 2016"

Key Words: Neuromyelitis optica, Neuromyelitis optica spectrum disorder, Cerebellar atrophy