No Evidence Disease Activity as a Treatment Target in Multiple Sclerosis

Bin, Chang Hun; Park, Min Su

J Mult Scler > Volume 6(2); 2015 > Article

Review Article

Journal of Multiple Sclerosis 2015;6(2):23-28.
Published online September 1, 2015.

다발성경화증 치료의 목표로서의 질병무활성증거

빈창훈, 박민수

영남대학교 의과대학 신경과학교실

No Evidence Disease Activity as a Treatment Target in Multiple Sclerosis

Chang Hun Bin, Min Su Park

Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea

Abstract

"No evidence of disease activity (NEDA) in multiple sclerosis (MS) means no relapse, no disability progression, and no new or enlarging lesions on MRI. NEDA is the treatment target in many inflammatorydiseases, such as rheumatoid arthritis and inflammatory bowel disease. Now, aggressiveearly disease modifying therapy is acceptable for treatment of MS to prevent the irreversibledamage that leads to disability. As new and more effective therapies for MS become available,the treatment paradigm of MS can be expected to shift, such that NEDA or freedom of disease activityand NEDA is becoming an important measure in clinical trials. NEDA is an important goal for treatingMS and a decision method of switching disease modifying therapy. There are many unsolvedproblems in NEDA and definition of NEDA would be changing by further new technologies andstudies. Journal of Multiple Sclerosis 6(2):23-28, 2015"

Key Words: No evidence of disease activity, Disease free state, Multiple sclerosis